The International School of Florence is organized into three divisions: the Junior School, the Middle School and the High School. The Junior School, including Pre-School, has its own campus in the nearby suburb of Bagno a Ripoli, while the Middle and High Schools share a brand new facility in central Florence. The Schools share some administration and faculty, but each offers an academically challenging curriculum appropriate to the needs of the age group it serves.

The variety and scope of the educational programs permit ISF students to follow an international curriculum or to prepare for Italian state exams, if so desired, and to prepare for university in the US and other countries around the world. The school offers the Primary Years Programme (PYP) and the Diploma Programme (DP), following the guidelines from the International Baccalaureate Organization (IBO).